PDB entry 4xo6

View 4xo6 on RCSB PDB site
Description: Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one
Class: oxidoreductase
Keywords: alpha-beta barrel, human 3-alpha hds3, akr, akr1c2, aldo-keto reductase, nadph, oxidoreductase
Deposited on 2015-01-16, released 2016-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C2
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C2, DDH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52895 (3-324)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d4xo6a1, d4xo6a2
  • Chain 'B':
    Compound: Aldo-keto reductase family 1 member C2
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C2, DDH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52895 (3-324)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d4xo6b1, d4xo6b2
  • Heterogens: NAP, 5SD, SO4, EDO, GOL, AOX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4xo6A (A:)
    svddskyqcvklndghfmpvlgfgtyapaevpkskaleavklaieagfhhidsahvynne
    eqvglairskiadgsvkredifytsklwsnshrpelvrpalerslknlqldyvdlylihf
    pvsvkpgeevipkdengkilfdtvdlcatweamekckdaglaksigvsnfnhrllemiln
    kpglkykpvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlled
    pvlcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidg
    lnrnvryltldifagppnypfsdey
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4xo6B (B:)
    svddskyqcvklndghfmpvlgfgtyapaevpkskaleavklaieagfhhidsahvynne
    eqvglairskiadgsvkredifytsklwsnshrpelvrpalerslknlqldyvdlylihf
    pvsvkpgeevipkdengkilfdtvdlcatweamekckdaglaksigvsnfnhrllemiln
    kpglkykpvcnqvechpyfnqrklldfckskdivlvaysalgshreepwvdpnspvlled
    pvlcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltseemkaidg
    lnrnvryltldifagppnypfsdey