PDB entry 4xm8

View 4xm8 on RCSB PDB site
Description: Anthrax toxin lethal factor with ligand-induced binding pocket
Class: toxin,hydrolase
Keywords: Anthrax toxin, lethal factor, metalloproteinase, metalloprotease, structural dynamics, ligand-induced conformational change, TOXIN, HYDROLASE
Deposited on 2015-01-14, released 2015-11-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: lef, pXO1-107, BXA0172, GBAA_pXO1_0172
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15917 (Start-514)
      • engineered mutation (4)
    Domains in SCOPe 2.07: d4xm8a1, d4xm8a2
  • Heterogens: 41T, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4xm8A (A:)
    snalsryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkr
    iqidssdflsteekeflkklqidirdslseeekellnriqvdssnplsekekeflkklkl
    diqpydinqrlqdtgglidspsinldvrkqykrdiqnidallhqsigstlynkiylyenm
    ninnltatlgadlvdstdntkinrgifnefkknfkysissnymivdinerpaldnerlkw
    riqlspdtragylengklilqrnigleikdvqiikqsekeyiridakvvpkskidtkiqe
    aqlninqewnkalglpkytklitfnvhnryasnivesaylilnewknniqsdlikkvtny
    lvdgngrfvftditlpniaeqythqdeiyeqvhskglyvpesrsillhgpskgvelrnds
    egfihefghavddyagylldknqsdlvtnskkfidifkeegsnltsygrtneaeffaeaf
    rlmhstdhaerlkvqknapktfqfindqikfiinslvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xm8A (A:)
    sryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqid
    sssteekeflkklqidirdslseeekellnplsekekeflkklkldiqpydinqrlqdtg
    glidspsinldvrkqykrdiqnidallhqsigstlynkiylyenmninnltatlgadlvd
    stdntkinrgifnefkknfkysissnymivdinerpaldnerlkwriqlspdtragylen
    gklilqrnigleikdvqiikqsekeyiridakvvpkskidtkiqeaqlninqewnkalgl
    pkytklitfnvhnryasnivesaylilnewknniqsdlikkvtnylvdgngrfvftditl
    pniaeqythqdeiyeqvhskglyvpesrsillhgpskgvelrndsegfihefghavddya
    gylldknqsdlvtnskkfidifkeegsnltsygrtneaeffaeafrlmhstdhaerlkvq
    knapktfqfindqikfiins