PDB entry 4xit

View 4xit on RCSB PDB site
Description: Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors
Class: Chaperone/chaperone Inhibitor
Keywords: CHAPERONE-CHAPERONE INHIBITOR complex
Deposited on 2015-01-07, released 2015-03-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-06-01, with a file datestamp of 2016-05-27.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock protein HSP 90-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HSP90AA1, HSP90A, HSPC1, HSPCA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4xita_
  • Heterogens: 40Z, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4xitA (A:)
    gslhmdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryes
    ltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealq
    agadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrg
    tkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xitA (A:)
    evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
    lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
    vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
    eyleerrikeivkkhsqfigypitlfve