PDB entry 4xi2

View 4xi2 on RCSB PDB site
Description: Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase
Class: transferase
Keywords: Kinase, Phosphorylation, Auto-inhibited, B-Cell development, X-linked agammaglobulinemia, TRANSFERASE
Deposited on 2015-01-06, released 2015-02-25
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.231
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Mus musculus [TaxId:10090]
    Gene: Btk, Bpk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4xi2a1, d4xi2a2
  • Heterogens: AU

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xi2A (A:)
telkkvvalydympmnandlqlrkgeeyfileesnlpwwrardkngqegyipsnyiteae
dsiemyewyskhmtrsqaeqllkqegkeggfivrdsskagkytvsvfakstgepqgvirh
yvvcstpqsqyylaekhlfstipelinyhqhnsaglisrlkypvskqnknapstaglgyg
sweidpkdltflkelgtgqfgvvkygkwrgqydvaikmiregsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmysk
fssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlaservytimysc
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    Sequence, based on observed residues (ATOM records): (download) 
    >4xi2A (A:)
telkkvvalydympmnandlqlrkgeeyfileesnlpwwrardkngqegyipsnyiteae
dsiemyewyskhmtrsqaeqlleggfivrdytvsvfakgvirhyvvcyylaekhlfstip
elinyhqhnsaglisrlkypvskqnknapstaglgygsweidpkdltflkelgtgqfgvv
kygkwrgqydvaikmiregsmsedefieeakvmmnlsheklvqlygvctkqrpifiitey
mangcllnylremrhrfqtqqllemckdvceameyleskqflhrdlaarnclvndqgvvk
vsdfglsryvlddeytssvgskfpvrwsppevlmyskfssksdiwafgvlmweiyslgkm
pyerftnsetaehiaqglrlyrphlaservytimyscwhekaderpsfkillsnildvmd
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