PDB entry 4xg8

View 4xg8 on RCSB PDB site
Description: Crystal structure of an inhibitor-bound Syk
Class: transferase/transferase inhibitor
Keywords: Syk kinase, Inhibitor, Spleen tyrosine kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-12-30, released 2015-12-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xg8a_
  • Chain 'C':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xg8c_
  • Heterogens: X8G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xg8A (A:)
eeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkd
ellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielv
hqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwp
vkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpa
gcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvnlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4xg8A (A:)
drklltledkelgsggtvkkgyyqmvvktvavkildpalkdellaeanvmqqldnpyivr
migiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfvhrd
laarnvllvtqhyakisdfglskalradenyykaqthpvkwyapecinyykfssksdvws
fgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydvenrp
gfaavelrlrnyyydvvn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4xg8C (C:)
eeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkd
ellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielv
hqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwp
vkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpa
gcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvnlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4xg8C (C:)
yldrklltledkelgsggtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqqldnp
yivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnf
vhrdlaarnvllvtqhyakisdfglskalradenyykaqpvkwyapecinyykfssksdv
wsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydven
rpgfaavelrlrny