PDB entry 4xg5

View 4xg5 on RCSB PDB site
Description: Crystal structure of an inhibitor-bound Syk
Class: transferase/transferase inhibitor
Keywords: Syk kinase, Inhibitor, Spleen tyrosine kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-12-30, released 2015-12-30
Made obsolete by 5ghv on 2016-07-06

The last revision prior to the SCOPe 2.05 freeze date was dated 2015-12-30, with a file datestamp of 2015-12-24.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4xg5a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4xg5b_
  • Heterogens: X5G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xg5A (A:)
eeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkd
ellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielv
hqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwp
vkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpa
gcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvnlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4xg5A (A:)
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilknpalkdellaeanvmqq
ldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyle
esnfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfs
sksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwt
ydvenrpgfaavelrlrnyyydvvn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4xg5B (B:)
eeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkd
ellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielv
hqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwp
vkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpa
gcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvnlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4xg5B (B:)
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilknpalkdellaeanvmqq
ldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyle
esnfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfs
sksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwt
ydvenrpgfaavelrlrnyyydvvn