PDB entry 4xcu

View 4xcu on RCSB PDB site
Description: Crystal Structure of FGFR4 with an Irreversible Inhibitor
Class: Transferase/Transferase Inhibitor
Keywords: Receptor Tyrosine Kinase, Hepatocellular carcinoma, Transferase-Transferase Inhibitor complex
Deposited on 2014-12-18, released 2015-04-01
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-04-01, with a file datestamp of 2015-03-27.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 4
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR4, JTK2, TKF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22455 (Start-293)
      • expression tag (294)
    Domains in SCOPe 2.05: d4xcua_
  • Heterogens: SO4, 40M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4xcuA (A:)
    mvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdparpdqastvavkmlkdn
    asdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflrarrpp
    gssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfglargv
    hhidyykktsngrlpvkwmapealfdrvythqsdvwsfgillweiftlggspypgipvee
    lfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvealdkvllavshhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xcuA (A:)
    dlpldplwefprdrlvlgkplgegqvvraeafgmdparpdqastvavkmlkdnasdkdla
    dlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflrarrppgssegpl
    sfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfglargvhhidyyk
    ktsngrlpvkwmapealfdrvythqsdvwsfgillweiftlggspypgipveelfsllre
    ghrmdrpphcppelyglmrecwhaapsqrptfkqlvealdkvllavsh