PDB entry 4xbc
View 4xbc on RCSB PDB site
Description: 1.60 A resolution structure of Norovirus 3CL protease complex with a covalently bound dipeptidyl inhibitor (1R,2S)-2-({N-[(benzyloxy)carbonyl]-3-cyclohexyl-L-alanyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (Hexagonal Form)
Class: hydrolase/hydrolase inhibitor
Keywords: PROTEASE, NOROVIRUS, NORWALK VIRUS, ANTIVIRAL INHIBITORS, DIPEPTIDYL INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2014-12-16, released
2015-03-25
The last revision prior to the SCOPe 2.06 freeze date was dated
2015-04-22, with a file datestamp of
2015-04-17.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 3C-like protease
Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
Gene: ORF1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4xbca1, d4xbca2 - Heterogens: M40, PG4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4xbcA (A:)
hhhhhhmapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale
Sequence, based on observed residues (ATOM records): (download)
>4xbcA (A:)
hmapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
gmlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqagegetale