PDB entry 4x6y

View 4x6y on RCSB PDB site
Description: Human soluble epoxide hydrolase in complex with a cyclopropyl urea derivative
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-12-09, released 2015-04-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-04-15, with a file datestamp of 2015-04-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional epoxide hydrolase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHX2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4x6ya_
  • Chain 'B':
    Compound: Bifunctional epoxide hydrolase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHX2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4x6yb_
  • Heterogens: S94, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4x6yA (A:)
    mkkghhhhhhtscnpsdmshgyvtvkprvrlhfvelgsgpavclchgfpeswyswryqip
    alaqagyrvlamdmkgygessappeieeycmevlckemvtfldklglsqavfighdwggm
    lvwymalfypervravaslntpfipanpnmsplesikanpvfdyqlyfqepgvaeaeleq
    nlsrtfkslfrasdesvlsmhkvceagglfvnspeepslsrmvteeeiqfyvqqfkksgf
    rgplnwyrnmernwkwackslgrkilipalmvtaekdfvlvpqmsqhmedwiphlkrghi
    edcghwtqmdkptevnqilikwldsdarnppvvskm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6yA (A:)
    tscnpsdmshgyvtvkprvrlhfvelgsgpavclchgfpeswyswryqipalaqagyrvl
    amdmkgygessappeieeycmevlckemvtfldklglsqavfighdwggmlvwymalfyp
    ervravaslntpfipanpnmsplesikanpvfdyqlyfqepgvaeaeleqnlsrtfkslf
    rasdesvlsmhkvceagglfvnspeepslsrmvteeeiqfyvqqfkksgfrgplnwyrnm
    ernwkwackslgrkilipalmvtaekdfvlvpqmsqhmedwiphlkrghiedcghwtqmd
    kptevnqilikwldsd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4x6yB (B:)
    mkkghhhhhhtscnpsdmshgyvtvkprvrlhfvelgsgpavclchgfpeswyswryqip
    alaqagyrvlamdmkgygessappeieeycmevlckemvtfldklglsqavfighdwggm
    lvwymalfypervravaslntpfipanpnmsplesikanpvfdyqlyfqepgvaeaeleq
    nlsrtfkslfrasdesvlsmhkvceagglfvnspeepslsrmvteeeiqfyvqqfkksgf
    rgplnwyrnmernwkwackslgrkilipalmvtaekdfvlvpqmsqhmedwiphlkrghi
    edcghwtqmdkptevnqilikwldsdarnppvvskm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6yB (B:)
    tscnpsdmshgyvtvkprvrlhfvelgsgpavclchgfpeswyswryqipalaqagyrvl
    amdmkgygessappeieeycmevlckemvtfldklglsqavfighdwggmlvwymalfyp
    ervravaslntpfipanpnmsplesikanpvfdyqlyfqepgvaeaeleqnlsrtfkslf
    rasdesvlsmhkvceagglfvnspeepslsrmvteeeiqfyvqqfkksgfrgplnwyrnm
    ernwkwackslgrkilipalmvtaekdfvlvpqmsqhmedwiphlkrghiedcghwtqmd
    kptevnqilikwldsd