PDB entry 4x6d

View 4x6d on RCSB PDB site
Description: CD1a ternary complex with endogenous lipids and BK6 TCR
Class: immune system
Keywords: CD1a, TCR, Immune complex, Lipid antigen, IMMUNE SYSTEM
Deposited on 2014-12-08, released 2015-01-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-03-04, with a file datestamp of 2015-02-27.
Experiment type: XRAY
Resolution: 2.98 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: T-cell surface glycoprotein CD1a
    Species: Homo sapiens [TaxId:9606]
    Gene: CD1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06126 (Start-274)
      • variant (9)
      • variant (47)
    Domains in SCOPe 2.06: d4x6da1, d4x6da2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4x6db_
  • Chain 'C':
    Compound: T-cell surface glycoprotein CD1a
    Species: Homo sapiens [TaxId:9606]
    Gene: CD1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06126
      • variant (9)
      • variant (47)
    Domains in SCOPe 2.06: d4x6dc1
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4x6dd_
  • Chain 'E':
    Compound: tcr alpha
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6D
    Domains in SCOPe 2.06: d4x6de1, d4x6de2
  • Chain 'F':
    Compound: tcr beta
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6D
    Domains in SCOPe 2.06: d4x6df1, d4x6df2
  • Chain 'G':
    Compound: tcr alpha
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6D
    Domains in SCOPe 2.06: d4x6dg1, d4x6dg2
  • Chain 'H':
    Compound: tcr beta
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6D
    Domains in SCOPe 2.06: d4x6dh1, d4x6dh2
  • Heterogens: OLA, PAM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4x6dA (A:)
    lkeplsfhviwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneew
    keletlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdf
    vsfqnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqr
    qvkpeawlshgpspgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtw
    ylratlevaageaadlscrvkhsslegqdivlywe
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dA (A:)
    plsfhviwiasfkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneewkeletlfr
    irtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdfvsfqnnsw
    lpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqrqvkpeawl
    shgpspgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtwylratlev
    aageaadlscrvkhsslegqdivlywe
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4x6dB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdkvehsdlsfskdwsfyllyyte
    ftptekdeyacrvnhvtlsqpkivkw
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4x6dC (C:)
    lkeplsfhviwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneew
    keletlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdf
    vsfqnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqr
    qvkpeawlshgpspgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtw
    ylratlevaageaadlscrvkhsslegqdivlywe
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dC (C:)
    plsfhviwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneewkel
    etlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdfvsf
    qnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqrqvk
    plshchvsgfypkpvwvqrgdilpsadgtwylratssl
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4x6dD (D:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dD (D:)
    iqrtpkiqvysflncyvsgfhpsdievdllkngeriekvehsdlsfskdwsfyllyytey
    acrvnhvtlsqpkivkwd
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4x6dE (E:)
    qkeveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgr
    ftaqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdp
    avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
    ksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dE (E:)
    eveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgrft
    aqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdpav
    yqlrdsvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsacanafnns
    iipedtffp
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4x6dF (F:)
    nagvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgev
    pdgynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnk
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dF (F:)
    gvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgevpd
    gynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnkvf
    ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
    alndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
    r
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4x6dG (G:)
    qkeveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgr
    ftaqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdp
    avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
    ksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dG (G:)
    eveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgrft
    aqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdpav
    yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
    dfacanafnnsiipedtffp
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4x6dH (H:)
    nagvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgev
    pdgynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnk
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6dH (H:)
    gvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgevpd
    gynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnkvf
    ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
    alndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
    ra