PDB entry 4x6c

View 4x6c on RCSB PDB site
Description: CD1a ternary complex with lysophosphatidylcholine and BK6 TCR
Class: immune system
Keywords: CD1a, TCR, Immune complex, Lipid antigen, IMMUNE SYSTEM
Deposited on 2014-12-08, released 2015-01-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-03-04, with a file datestamp of 2015-02-27.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: T-cell surface glycoprotein CD1a
    Species: Homo sapiens [TaxId:9606]
    Gene: CD1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06126 (Start-274)
      • variant (9)
      • variant (47)
    Domains in SCOPe 2.06: d4x6ca1, d4x6ca2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4x6cb_
  • Chain 'C':
    Compound: T-cell surface glycoprotein CD1a
    Species: Homo sapiens [TaxId:9606]
    Gene: CD1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06126
      • variant (9)
      • variant (47)
    Domains in SCOPe 2.06: d4x6cc1
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4x6cd_
  • Chain 'E':
    Compound: tcr alpha
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6C
    Domains in SCOPe 2.06: d4x6ce1, d4x6ce2
  • Chain 'F':
    Compound: tcr beta
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6C (0-End)
    Domains in SCOPe 2.06: d4x6cf1, d4x6cf2
  • Chain 'G':
    Compound: tcr alpha
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6C
    Domains in SCOPe 2.06: d4x6cg1, d4x6cg2
  • Chain 'H':
    Compound: tcr beta
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 4X6C
    Domains in SCOPe 2.06: d4x6ch1, d4x6ch2
  • Heterogens: NAG, 42H, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4x6cA (A:)
    lkeplsfhviwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneew
    keletlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdf
    vsfqnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqr
    qvkpeawlshgpspgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtw
    ylratlevaageaadlscrvkhsslegqdivlywegslvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cA (A:)
    plsfhviwianlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneewkeletlfrirti
    rsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdfvsfqnnswlpyp
    vagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqrqvkpeawlshgp
    spgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtwylratlevaage
    aadlscrvkhsslegqdivlywe
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4x6cB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdmgslvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4x6cC (C:)
    lkeplsfhviwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneew
    keletlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdf
    vsfqnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqr
    qvkpeawlshgpspgpghlqlvchvsgfypkpvwvmwmrgeqeqqgtqrgdilpsadgtw
    ylratlevaageaadlscrvkhsslegqdivlywegslvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cC (C:)
    plsfhviwiasfynhswkqnlvsgwlsdlqthtwdsnsstivflwpwsrgnfsneewkel
    etlfrirtirsfegirryahelqfeypfeiqvtggcelhsgkvsgsflqlayqgsdfvsf
    qnnswlpypvagnmakhfckvlnqnqhendithnllsdtcprfilglldagkahlqrqvk
    peawlshqlvchvsgfypkpvwvmwmrgeqrgdilpsadgtwylratledlscrvkhssl
    egqdivlyw
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4x6cD (D:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdmgslvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cD (D:)
    iqrtpkiqvysrhflncyvsgfhpsdievdllkngeriekvehsdlsfskdwsfyllyyt
    eftptekdeyacrvnhvtlsqpkivkwdrd
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4x6cE (E:)
    qkeveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgr
    ftaqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdp
    avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
    ksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cE (E:)
    keveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgrf
    taqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdpa
    vyqlrddksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
    canafnnsiipedtffps
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4x6cF (F:)
    nagvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgev
    pdgynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnk
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cF (F:)
    nagvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgev
    pdgynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnk
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgr
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4x6cG (G:)
    qkeveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgr
    ftaqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdp
    avyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsn
    ksdfacanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cG (G:)
    keveqdpgplsvpegaivslnctysnsafqyfmwyrqysrkgpellmytyssgnkedgrf
    taqvdksskyislfirdsqpsdsatylcamstslpnagkstfgdgttltvkpniqnpdpa
    vyqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnk
    sdfacanafnnsiipedtffp
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4x6cH (H:)
    nagvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgev
    pdgynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnk
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >4x6cH (H:)
    agvtqtpkfrvlktgqsmtllcaqdmnheymywyrqdpgmglrlihysvgegttakgevp
    dgynvsrlkkqnfllglesaapsqtsvyfcasryflptqgmgaffgqgtrltvvedlnkv
    fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
    palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
    gra