PDB entry 4x2n

View 4x2n on RCSB PDB site
Description: Selection of fragments for kinase inhibitor design: decoration is key
Class: transferase
Keywords: transferase, protein kinase, inhibitor complex
Deposited on 2014-11-26, released 2014-12-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-01-21, with a file datestamp of 2015-01-16.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.163
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1, ALK5, SKR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36897 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.06: d4x2na1, d4x2na2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4x2nA (A:)
gtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhen
ilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhm
eivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkry
mapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsv
eemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq
egikm

    Sequence, based on observed residues (ATOM records): (download) 
    >4x2nA (A:)
gtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhen
ilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhm
eivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkry
mapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsv
eemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq
egi