PDB entry 4x2f

View 4x2f on RCSB PDB site
Description: Selection of fragments for kinase inhibitor design: decoration is key
Class: Transferase/Transferase Inhibitor
Keywords: TRANSFERASE, PROTEIN KINASE, INHIBITOR COMPLEX, Transferase-Transferase Inhibitor complex
Deposited on 2014-11-26, released 2015-10-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-10-28, with a file datestamp of 2015-10-23.
Experiment type: XRAY
Resolution: 1.49 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFBR1, ALK5, SKR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36897 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d4x2fa1, d4x2fa2
  • Heterogens: 3WJ, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4x2fA (A:)
gtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhen
ilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhm
eivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkry
mapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsv
eemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq
egikm

    Sequence, based on observed residues (ATOM records): (download) 
    >4x2fA (A:)
gtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhen
ilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhm
eivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkry
mapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsv
eemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq
egi