PDB entry 4x25

View 4x25 on RCSB PDB site
Description: Structural basis for mutation-induced destabilization of Profilin 1 in ALS
Class: protein binding
Keywords: Human Profilin-1 M114T Mutant ALS, PROTEIN BINDING
Deposited on 2014-11-25, released 2015-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-25, with a file datestamp of 2018-04-20.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Profilin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PFN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07737 (Start-139)
      • engineered mutation (113)
    Domains in SCOPe 2.08: d4x25a_
  • Chain 'B':
    Compound: Profilin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PFN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07737 (Start-139)
      • engineered mutation (113)
    Domains in SCOPe 2.08: d4x25b_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4x25A (A:)
magwnayidnlmadgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfy
vngltlggqkcsvirdsllqdgefsmdlrtkstggaptfnvtvtktdktlvlltgkegvh
gglinkkcyemashlrrsqy

    Sequence, based on observed residues (ATOM records): (download) 
    >4x25A (A:)
agwnayidnlmadgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfyv
ngltlggqkcsvirdsllqdgefsmdlrtkstfnvtvtktdktlvlltgkegvhgglink
kcyemashlrrsqy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4x25B (B:)
magwnayidnlmadgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfy
vngltlggqkcsvirdsllqdgefsmdlrtkstggaptfnvtvtktdktlvlltgkegvh
gglinkkcyemashlrrsqy

    Sequence, based on observed residues (ATOM records): (download) 
    >4x25B (B:)
agwnayidnlmdgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfyvn
gltlggqkcsvirdsllqdgefsmdlrttfnvtvtktdktlvlltgkegvhgglinkkcy
emashlrrsqy