PDB entry 4x24

View 4x24 on RCSB PDB site
Description: Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase, hydrolase-hydrolase inhibitor complex
Deposited on 2014-11-25, released 2015-08-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Species: Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) [TaxId:345073]
    Gene: mtnN, pfs, VC0395_A1957, VC395_2494
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5F5R2 (0-230)
      • engineered mutation (112)
      • engineered mutation (152)
      • engineered mutation (157)
      • expression tag (231-236)
    Domains in SCOPe 2.07: d4x24a1, d4x24a2
  • Chain 'B':
    Compound: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Species: Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) [TaxId:345073]
    Gene: mtnN, pfs, VC0395_A1957, VC395_2494
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5F5R2 (0-230)
      • engineered mutation (112)
      • engineered mutation (152)
      • engineered mutation (157)
      • expression tag (231-236)
    Domains in SCOPe 2.07: d4x24b1, d4x24b2
  • Heterogens: TDI, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4x24A (A:)
mkigiigamqqevailkdliedvqevnqagctfysgqiqgvdvvllqsgigkvsaalgta
llisqyapdvvintgsaggfdaslnvgdvvissevrhhdadvtafgyeigqmpgqpaafk
adeklmtvaeqalaqlpnthavrglictgdafictaegqqfirqhfpsvvavemeasaia
qtchqfkvpfvvvraisdvadkesplsfeeflplaaksssamvlkmvellkenlyfqghh
hhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4x24A (A:)
mkigiigamqqevailkdliedvqevnqagctfysgqiqgvdvvllqsgigkvsaalgta
llisqyapdvvintgsaggfdaslnvgdvvissevrhhdadvtafgyeigqmpgqpaafk
adeklmtvaeqalaqlpnthavrglictgdafictaegqqfirqhfpsvvavemeasaia
qtchqfkvpfvvvraisdvadkesplsfeeflplaaksssamvlkmvellkenlyfq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4x24B (B:)
mkigiigamqqevailkdliedvqevnqagctfysgqiqgvdvvllqsgigkvsaalgta
llisqyapdvvintgsaggfdaslnvgdvvissevrhhdadvtafgyeigqmpgqpaafk
adeklmtvaeqalaqlpnthavrglictgdafictaegqqfirqhfpsvvavemeasaia
qtchqfkvpfvvvraisdvadkesplsfeeflplaaksssamvlkmvellkenlyfqghh
hhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4x24B (B:)
mkigiigamqqevailkdliedvqevnqagctfysgqiqgvdvvllqsgigkvsaalgta
llisqyapdvvintgsaggfdaslnvgdvvissevrhhdadvtafgyeigqmpgqpaafk
adeklmtvaeqalaqlpnthavrglictgdafictaegqqfirqhfpsvvavemeasaia
qtchqfkvpfvvvraisdvadkesplsfeeflplaaksssamvlkmvellkenlyfq