PDB entry 4wzv

View 4wzv on RCSB PDB site
Description: Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain
Class: hydrolase
Keywords: MMP9 Inhibitor complex, Thyroid hormone-binding protein, hydrolase
Deposited on 2014-11-20, released 2015-08-26
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-10-07, with a file datestamp of 2015-10-02.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Matrix metalloproteinase-9,Matrix metalloproteinase-9
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP9, CLG4B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wzva_
  • Chain 'B':
    Compound: Matrix metalloproteinase-9,Matrix metalloproteinase-9
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP9, CLG4B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wzvb_
  • Heterogens: E40, ZN, CA, EDO, PGO, PEG, AZI, NA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wzvA (A:)
fegdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviq
fgvaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgvgyslflvaahefg
halgldhssvpealmypmyrftegpplhkddvngirhlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >4wzvA (A:)
gdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviqfg
vaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgvgyslflvaahefgha
lgldhssvpealmypmyrftegpplhkddvngirhlyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wzvB (B:)
fegdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviq
fgvaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgvgyslflvaahefg
halgldhssvpealmypmyrftegpplhkddvngirhlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >4wzvB (B:)
gdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviqfg
vaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgvgyslflvaahefgha
lgldhssvpealmypmyrftegpplhkddvngirhlyg