PDB entry 4wxr

View 4wxr on RCSB PDB site
Description: X-ray crystal structure of NS3 Helicase from HCV with a bound inhibitor at 2.42 A resolution
Class: hydrolase/hydrolase inhibitor
Keywords: Helicase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-11-14, released 2015-12-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-12-23, with a file datestamp of 2015-12-18.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ns3
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wxra1, d4wxra2
  • Chain 'B':
    Compound: ns3
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wxrb1, d4wxrb2
  • Heterogens: 3VZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wxrA (A:)
rspvftdnssppavpqsfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfg
aymskahgvdpnirtgvrtittgspitystygkfladggcsggaydiiicdechstdats
ilgigtvldqaetagarlvvlatatppgsvtvshpnieevalsttgeipfygkaiplevi
kggrhlifchskkkcdelaaklvalginavayyrgldvsviptsgdvvvvstdalmtgft
gdfdsvidcntcvtqtvdfsldptftietttlpqdavsrtqrrgrtgrgkpgiyrfvapg
erpsgmfdssvlcecydagcawyeltpaettvrlraymntpglpvcqdhlefwegvftgl
thidahflsqtkqsgenfpylvayqatvcaraqapppswdqmwkclirlkptlhgptpll
yrlgavqnevtlthpitkyimtcmsadlevv

    Sequence, based on observed residues (ATOM records): (download) 
    >4wxrA (A:)
ppavpqsfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfgaymskdpnir
tgvrtittgspitystygkfladggcsaydiiicdechstdatsilgigtvldqaetaga
rlvvlatatppgsvtvshpnieevalsttgeipfygkaiplevikggrhlifchskkkcd
elaaklvalginavayyrgldvsviptsgdvvvvstdatgdfdsvidcntcvtqtvdfsl
dptftietttlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagca
wyeltpaettvrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpyl
vayqatvcaraqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyim
tcmsadl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wxrB (B:)
rspvftdnssppavpqsfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfg
aymskahgvdpnirtgvrtittgspitystygkfladggcsggaydiiicdechstdats
ilgigtvldqaetagarlvvlatatppgsvtvshpnieevalsttgeipfygkaiplevi
kggrhlifchskkkcdelaaklvalginavayyrgldvsviptsgdvvvvstdalmtgft
gdfdsvidcntcvtqtvdfsldptftietttlpqdavsrtqrrgrtgrgkpgiyrfvapg
erpsgmfdssvlcecydagcawyeltpaettvrlraymntpglpvcqdhlefwegvftgl
thidahflsqtkqsgenfpylvayqatvcaraqapppswdqmwkclirlkptlhgptpll
yrlgavqnevtlthpitkyimtcmsadlevv

    Sequence, based on observed residues (ATOM records): (download) 
    >4wxrB (B:)
dnssppavpqsfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfgaymska
hdpnirtgvrtittgspitystygkfladggcsggaydiiicdechstdatsilgigtvl
dqaetagarlvvlatatppgsvtvshpnieevalsttgeipfygkaiplevikggrhlif
chskkkcdelaaklvalginavayyrgldvsviptsgdvvvvstdaltgdfdsvidcntc
vtqtvdfsldptftietttlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvl
cecydagcawyeltpaettvrlraymntpglpvcqdhlefwegvftglthidahflsqtk
qsgenfpylvayqatvcaraqapppswdqmwkclirlkptlhgptpllyrlgavqnevtl
thpitkyimtcmsadlev