PDB entry 4wxp

View 4wxp on RCSB PDB site
Description: X-ray crystal structure of NS3 Helicase from HCV with a bound fragment inhibitor at 2.08 A resolution
Class: hydrolase/hydrolase inhibitor
Keywords: Helicase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-11-14, released 2015-12-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-12-23, with a file datestamp of 2015-12-18.
Experiment type: XRAY
Resolution: 2.08 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NS3-4 protease
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot K7XFN2 (Start-450)
      • conflict (16)
      • conflict (68)
      • conflict (78)
      • conflict (83)
      • conflict (152)
      • conflict (178)
      • conflict (180)
      • conflict (203)
      • conflict (267)
      • conflict (290)
      • conflict (404)
      • conflict (406)
      • conflict (413)
      • conflict (415)
      • conflict (425)
    Domains in SCOPe 2.08: d4wxpa1, d4wxpa2
  • Heterogens: NA, CL, 3VY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wxpA (A:)
rspvftdnssppavpqsfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfg
vymskahgidpnirtgvraittggpitystygkfladggcsggaydiiicdechstdsts
ilgigtvldqaetagarlvvlatatppgsvtvshpnieevalsntgeipfygkaipievi
rggrhlifchskkkcdelaaklsalglnavayyrgldvsviptsgdvvvvatdalmtgyt
gdfdsvidcntcvtqtvdfsldptftidtttvpqdavsrsqrrgrtgrgrrgiyrfvtpg
erpsgmfdssvlcecydagcawyeltpaetsvrlraylntpglpvcqdhlefwesvftgl
thidahflsqtkqagdnfpylvayqatvcaraqapppswdqmwksltrlkptllgptpll
yrlgalqnevtlthpitkyimacmsadlevv

    Sequence, based on observed residues (ATOM records): (download) 
    >4wxpA (A:)
dnssppavpqsfqvahlhaptgsgkstkvpaayaaqgykvlvlnpsvaatlgfgvymska
hgidpnirtgvraittggpitystygkfladggcsggaydiiicdechstdstsilgigt
vldqaetagarlvvlatatppgsvtvshpnieevalsntgeipfygkaipievirggrhl
ifchskkkcdelaaklsalglnavayyrgldvsviptsgdvvvvatdalmtgytgdfdsv
idcntcvtqtvdfsldptftidtttvpqdavsrsqrrgrtgrgrrgiyrfvtpgerpsgm
fdssvlcecydagcawyeltpaetsvrlraylntpglpvcqdhlefwesvftglthidah
flsqtkqagdnfpylvayqatvcaraqapppswdqmwksltrlkptllgptpllyrlgal
qnevtlthpitkyimacmsadlevv