PDB entry 4wxh

View 4wxh on RCSB PDB site
Description: Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T
Class: transferase
Keywords: methyltransferase, mono-oxygenase, SAH binding, antibiotic binding, transferase
Deposited on 2014-11-13, released 2015-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-02-28, with a file datestamp of 2018-02-23.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carminomycin 4-O-methyltransferase DnrK
    Species: Streptomyces peucetius [TaxId:1950]
    Gene: dnrk
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06528
      • insertion (307)
    Domains in SCOPe 2.08: d4wxha1, d4wxha2
  • Chain 'B':
    Compound: Carminomycin 4-O-methyltransferase DnrK
    Species: Streptomyces peucetius [TaxId:1950]
    Gene: dnrk
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06528
      • insertion (307)
    Domains in SCOPe 2.08: d4wxhb1, d4wxhb2
  • Heterogens: SAH, 3VL, DTU, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wxhA (A:)
mahhhhhhhrstaeptvaarpqqidalrtlirlgslhtpmvvrtaatlrlvdhilagart
vkalaartdtrpeallrlirhlvaiglleedapgefvptevgelladdhpaaqrawhdlt
qavaradisftrlpdairtgrptyesiygkpfyedlagrpdlrasfdsllacdqdvafda
paaaydwtnvrhvldvgggkggfaaaiarraphvsatvlemagtvdtarsylkdeglsdr
vdvvegdffeplprkadaiilsfvllnwpdhdavriltrcaealepggriliherddlhe
nsfneqfsteldlrmlvflggalrtrekwdglaasaglvveevrqlpsptipydlsllvl
apaatga

    Sequence, based on observed residues (ATOM records): (download) 
    >4wxhA (A:)
rpqqidalrtlirlgslhtpmvvrtaatlrlvdhilagartvkalaartdtrpeallrli
rhlvaiglleedapgefvptevgelladdhpaaqrawhdltqavaradisftrlpdairt
grptyesiygkpfyedlagrpdlrasfdsllacdqdvafdapaaaydwtnvrhvldvggg
kggfaaaiarraphvsatvlemagtvdtarsylkdeglsdrvdvvegdffeplprkadai
ilsfvllnwpdhdavriltrcaealepggriliherddlhensfneqfsteldlrmlvfl
ggalrtrekwdglaasaglvveevrqlpsptipydlsllvlapa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wxhB (B:)
mahhhhhhhrstaeptvaarpqqidalrtlirlgslhtpmvvrtaatlrlvdhilagart
vkalaartdtrpeallrlirhlvaiglleedapgefvptevgelladdhpaaqrawhdlt
qavaradisftrlpdairtgrptyesiygkpfyedlagrpdlrasfdsllacdqdvafda
paaaydwtnvrhvldvgggkggfaaaiarraphvsatvlemagtvdtarsylkdeglsdr
vdvvegdffeplprkadaiilsfvllnwpdhdavriltrcaealepggriliherddlhe
nsfneqfsteldlrmlvflggalrtrekwdglaasaglvveevrqlpsptipydlsllvl
apaatga

    Sequence, based on observed residues (ATOM records): (download) 
    >4wxhB (B:)
qqidalrtlirlgslhtpmvvrtaatlrlvdhilagartvkalaartdtrpeallrlirh
lvaiglleeapgefvptevgelladdhpaaqrawhdltqavaradisftrlpdairtgrp
tyesiygkpfyedlagrpdlrasfdsllacdqdvafdapaaaydwtnvrhvldvgggkgg
faaaiarraphvsatvlemagtvdtarsylkdeglsdrvdvvegdffeplprkadaiils
fvllnwpdhdavriltrcaealepggriliherddlensfneqfsteldlrmlvflggal
rtrekwdglaasaglvveevrqlpsptipydlsllvlapa