PDB entry 4wwp

View 4wwp on RCSB PDB site
Description: Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine
Class: transferase/transferase inhibitor
Keywords: kinase, phosphotransfer, PIP2
Deposited on 2014-11-11, released 2014-12-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-01-28, with a file datestamp of 2015-01-23.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.213
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wwpa1, d4wwpa2, d4wwpa3, d4wwpa4
  • Heterogens: SO4, 3VE, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wwpA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeew
plvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvfv
eaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapalss
kasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadklt
satnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatdp
lnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsald
vgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfllk
rglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqviemlq
kvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckv
maskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlc
llpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqa
averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginkerv
pfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlt
skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwpA (A:)
qafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskpl
peylwkkianncifivihrsttsqtikvspddtpgailqvlrvcgrdeylvgetpiknfq
wvrhclkngeeihvvldtppdpaldevrkeetvslwdcdrkfrvkirgidipvlltvfve
aniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkkvqllyy
vnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisilldnempnqlrk
qleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllar
revwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyh
dsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdft
qqvqviemlqkvtldikslsdvssqvisqlkqklenlqnsqlpesfrvpydpglkagala
iekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwet
esldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspt
eekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghikervpfvlt
pdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmptskediey
irdaltvgkneedakkyfldqievcrdkgwtvqfnwflhl