PDB entry 4wwi

View 4wwi on RCSB PDB site
Description: Crystal structure of the C domain of staphylococcal protein A in complex with the Fc fragment of human IgG at 2.3 Angstrom resolution
Class: protein binding
Keywords: three-helix bundle, conformational heterogeneity, S. aureus, antibody binding, PROTEIN BINDING
Deposited on 2014-11-11, released 2015-07-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Immunoglobulin G-binding protein A
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: SPA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wwia_
  • Chain 'B':
    Compound: Immunoglobulin G-binding protein A
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: SPA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wwib_
  • Chain 'C':
    Compound: Immunoglobulin G-binding protein A
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: SPA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wwic_
  • Chain 'D':
    Compound: Ig gamma-3 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01860 (0-End)
      • conflict (197-198)
    Domains in SCOPe 2.08: d4wwid1, d4wwid2
  • Chain 'E':
    Compound: Ig gamma-3 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01860
      • conflict (197-198)
    Domains in SCOPe 2.08: d4wwie1, d4wwie2
  • Chain 'F':
    Compound: Ig gamma-3 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01860 (0-End)
      • conflict (58)
      • conflict (197-198)
    Domains in SCOPe 2.08: d4wwif1, d4wwif2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wwiA (A:)
adnkfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwiA (A:)
dnkfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wwiB (B:)
adnkfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwiB (B:)
nkfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4wwiC (C:)
adnkfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwiC (C:)
kfnkeqqnafyeilhlpnlteeqrngfiqslkddpsvskeilaeakklndaqapk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4wwiD (D:)
psvflfppkpkdtlmisrtpevtcvvvdvshedpevqfkwyvdgvevhnaktkpreeqfn
stfrvvsvltvlhqdwlngkeykckvsnkalpapiektisktkgqprepqvytlppsree
mtknqvsltclvkgfypsdiavewessgqpennynttppmldsdgsfflyskltvdksrw
qqgnifscsvmhealhnhytqkslslspgkgslehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwiD (D:)
psvflfppkpkdtlmisrtpevtcvvvdvshedpevqfkwyvdgvevhnaktkpreervv
svltvlhqdwlngkeykckvsnkalpapiektisktkgqprepqvytlppsreemtknqv
sltclvkgfypsdiavewessgqpennynttppmldsdgsfflyskltvdksrwqqgnif
scsvmhealhnhytqkslsls

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4wwiE (E:)
psvflfppkpkdtlmisrtpevtcvvvdvshedpevqfkwyvdgvevhnaktkpreeqfn
stfrvvsvltvlhqdwlngkeykckvsnkalpapiektisktkgqprepqvytlppsree
mtknqvsltclvkgfypsdiavewessgqpennynttppmldsdgsfflyskltvdksrw
qqgnifscsvmhealhnhytqkslslspgkgslehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwiE (E:)
vflfppkpkdtlmisrtpevtcvvvdfkwyvdgvevhnaktkprvvsvltvlhqdwlngk
eykckviektisktkgqprepqvytlppsreemtknqvsltclvkgfypsdiavewessg
qpennynttppmldsdgsfflyskltvdksrwqqgnifscsvmhealhnhytqkslsls

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4wwiF (F:)
psvflfppkpkdtlmisrtpevtcvvvdvshedpevqfkwyvdgvevhnaktkpreeqfn
stfrvvsvltvlhqdwlngkeykckvsnkalpapiektisktkgqprepqvytlppsree
mtknqvsltclvkgfypsdiavewessgqpennynttppmldsdgsfflyskltvdksrw
qqgnifscsvmhealhnhytqkslslspgkgslehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4wwiF (F:)
psvflfppkpkdtlmisrtpevtcvvvdvshedpevqfkwyvdgvevhnaktkpreeqfn
stfrvvsvltvlhqdwlngkeykckvsnkalpapiektisktkgqprepqvytlppsree
mtknqvsltclvkgfypsdiavewessgqpennynttppmldsdgsfflyskltvdksrw
qqgnifscsvmhealhnhytqkslsls