PDB entry 4wvf

View 4wvf on RCSB PDB site
Description: Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
Class: transport protein/transport protein inhibitor
Keywords: CRM1, inhibitor, SINE, KPT, TRANSPORT PROTEIN-TRANSPORT PROTEIN INHIBITOR complex
Deposited on 2014-11-05, released 2015-07-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-07-15, with a file datestamp of 2015-07-10.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wvfa_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:559292]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4wvfb_
  • Chain 'C':
    Compound: Crm1p
    Species: Saccharomyces cerevisiae [TaxId:1182966]
    Gene: Crm1, R008_G21866
    Database cross-references and differences (RAF-indexed):
    • Uniprot W7PTE1 (3-End)
      • expression tag (1-2)
      • engineered mutation (504)
      • cloning artifact (987)
  • Heterogens: GNP, MG, EDO, GOL, K76, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4wvfA (A:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4wvfA (A:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vmdpalaaqyehdlevaqttalpdedddl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4wvfB (B:)
    dihfepvvhlekvdvktmeedeevlykvraklfrfdadakewkergtgdckflknkktnk
    vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
    enadkfkeefekaqeinkka
    

    Sequence, based on observed residues (ATOM records): (download)
    >4wvfB (B:)
    ihfepvvtmeedeevlykvraklfrfdadakewkergtgdckflknkktnkvrilmrrdk
    tlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkee
    fekaqeinkk
    

  • Chain 'C':
    No sequence available.