PDB entry 4wt6

View 4wt6 on RCSB PDB site
Description: Crystal structure of human Pim-1 kinase in complex with a thiadiazolamine-indole inhibitor.
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE, serine/threonine protein kinase
Deposited on 2014-10-29, released 2015-02-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-11, with a file datestamp of 2015-02-06.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.178
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wt6a_
  • Heterogens: 3U6, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wt6A (A:)
mahhhhhhdevdgplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwge
lpngtrvpmevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergal
qeelarsffwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvyt
dfdgtrvysppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrv
ssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlh

    Sequence, based on observed residues (ATOM records): (download) 
    >4wt6A (A:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlh