PDB entry 4wki
View 4wki on RCSB PDB site
Description: Crystal structure of human ADAMTS-4 in complex with inhibitor 5-CHLORO-N-{[(4S)-4-(1-METHYL-1H-IMIDAZOL-2-YL)-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}-1-BENZOFURAN-2-CARBOXAMIDE (compound 11)
Class: hydrolase/hydrolase inhibitor
Keywords: Metalloprotease, Osteoarthritis, Inhibitor
Deposited on
2014-10-02, released
2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-01-14, with a file datestamp of
2015-01-09.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.2
AEROSPACI score: 0.48
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: A disintegrin and metalloproteinase with thrombospondin motifs 4
Species: Homo sapiens [TaxId:9606]
Gene: ADAMTS4, KIAA0688, UNQ769/PRO1563
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4wkia_ - Heterogens: ZN, CA, EDO, 3PW, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4wkiA (A:)
faslsrfvetlvvaddkmaafhgaglkrylltvmaaaakafkhpsirnpvslvvtrlvil
gsgeegpqvgpsaaqtlrsfcawqrglntpedsdpdhfdtailftrqdlcgvstcdtlgm
advgtvcdparscaiveddglqsaftaahelghvfnmlhdnskpcislngplstsrhvma
pvmahvdpeepwspcsarfitdfldngyghclldkpeaplhlpvtfpdvhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4wkiA (A:)
slsrfvetlvvaddkmaafhgaglkrylltvmaaaakafkhpsirnpvslvvtrlvilgp
qvgpsaaqtlrsfcawqrglntpedsdpdhfdtailftrqdlcgvstcdtlgmadvgtvc
dparscaiveddglqsaftaahelghvfnmlhdnskpcislngplsrhvmapvmahvdpe
epwspcsarfitdfldngyghclldkpeaplhlp