PDB entry 4wjg

View 4wjg on RCSB PDB site
Description: Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin
Class: endocytosis
Keywords: Endocytosis, Trypanosome, Receptor
Deposited on 2014-09-30, released 2014-11-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain '1':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjg1_
  • Chain '2':
    Compound: Haptoglobin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain '3':
    Compound: Iron-regulated surface determinant protein H
    Species: Staphylococcus aureus subsp. aureus N315 [TaxId:158879]
    Gene: isdH, harA, sasI, SA1552
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjg3_
  • Chain '4':
    Compound: Haptoglobin-hemoglobin receptor
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Gene: HpHbR
    Database cross-references and differences (RAF-indexed):
  • Chain 'A':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjga_
  • Chain 'B':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgb_
  • Chain 'C':
    Compound: Haptoglobin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Iron-regulated surface determinant protein H
    Species: Staphylococcus aureus subsp. aureus N315 [TaxId:158879]
    Gene: isdH, harA, sasI, SA1552
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgd_
  • Chain 'E':
    Compound: Haptoglobin-hemoglobin receptor
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Gene: HpHbR
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgf_
  • Chain 'G':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgg_
  • Chain 'H':
    Compound: Haptoglobin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Iron-regulated surface determinant protein H
    Species: Staphylococcus aureus subsp. aureus N315 [TaxId:158879]
    Gene: isdH, harA, sasI, SA1552
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgi_
  • Chain 'J':
    Compound: Haptoglobin-hemoglobin receptor
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Gene: HpHbR
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgk_
  • Chain 'L':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgl_
  • Chain 'M':
    Compound: Haptoglobin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Iron-regulated surface determinant protein H
    Species: Staphylococcus aureus subsp. aureus N315 [TaxId:158879]
    Gene: isdH, harA, sasI, SA1552
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgn_
  • Chain 'O':
    Compound: Haptoglobin-hemoglobin receptor
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Gene: HpHbR
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgp_
  • Chain 'Q':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgq_
  • Chain 'R':
    Compound: Haptoglobin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: Iron-regulated surface determinant protein H
    Species: Staphylococcus aureus subsp. aureus N315 [TaxId:158879]
    Gene: isdH, harA, sasI, SA1552
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgs_
  • Chain 'T':
    Compound: Haptoglobin-hemoglobin receptor
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Gene: HpHbR
    Database cross-references and differences (RAF-indexed):
  • Chain 'U':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgu_
  • Chain 'V':
    Compound: Hemoglobin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgv_
  • Chain 'W':
    Compound: Haptoglobin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'X':
    Compound: Iron-regulated surface determinant protein H
    Species: Staphylococcus aureus subsp. aureus N315 [TaxId:158879]
    Gene: isdH, harA, sasI, SA1552
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgx_
  • Chain 'Y':
    Compound: Haptoglobin-hemoglobin receptor
    Species: Trypanosoma brucei brucei [TaxId:5702]
    Gene: HpHbR
    Database cross-references and differences (RAF-indexed):
  • Chain 'Z':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wjgz_
  • Heterogens: HEM, OXY, NAG

PDB Chain Sequences:

  • Chain '1':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjg1 (1:)
vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
eftppvqaayqkvvagvanalahkyh

  • Chain '2':
    No sequence available.

  • Chain '3':
    Sequence, based on SEQRES records: (download) 
    >4wjg3 (3:)
gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
iddgeetnydytklvfakpiyndpsl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wjg3 (3:)
adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
dgeetnydytklvfakpiyndpsl

  • Chain '4':
    No sequence available.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgA (A:)
vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
vhasldkflasvstvltskyr

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgB (B:)
vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
eftppvqaayqkvvagvanalahkyh

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4wjgD (D:)
gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
iddgeetnydytklvfakpiyndpsl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wjgD (D:)
adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
dgeetnydytklvfakpiyndpsl

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgF (F:)
vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
vhasldkflasvstvltskyr

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgG (G:)
vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
eftppvqaayqkvvagvanalahkyh

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4wjgI (I:)
gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
iddgeetnydytklvfakpiyndpsl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wjgI (I:)
adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
dgeetnydytklvfakpiyndpsl

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgK (K:)
vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
vhasldkflasvstvltskyr

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgL (L:)
vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
eftppvqaayqkvvagvanalahkyh

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >4wjgN (N:)
gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
iddgeetnydytklvfakpiyndpsl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wjgN (N:)
adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
dgeetnydytklvfakpiyndpsl

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgP (P:)
vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
vhasldkflasvstvltskyr

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgQ (Q:)
vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
eftppvqaayqkvvagvanalahkyh

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >4wjgS (S:)
gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
iddgeetnydytklvfakpiyndpsl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wjgS (S:)
adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
dgeetnydytklvfakpiyndpsl

  • Chain 'T':
    No sequence available.

  • Chain 'U':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgU (U:)
vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
vhasldkflasvstvltskyr

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgV (V:)
vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
eftppvqaayqkvvagvanalahkyh

  • Chain 'W':
    No sequence available.

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >4wjgX (X:)
gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
iddgeetnydytklvfakpiyndpsl

    Sequence, based on observed residues (ATOM records): (download) 
    >4wjgX (X:)
adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
dgeetnydytklvfakpiyndpsl

  • Chain 'Y':
    No sequence available.

  • Chain 'Z':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wjgZ (Z:)
vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
vhasldkflasvstvltskyr