PDB entry 4whw

View 4whw on RCSB PDB site
Description: Direct photocapture of bromodomains using tropolone chemical probes
Class: transcription/transcription inhibitor
Keywords: BROMO domain, BRD4, inhibitor, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Deposited on 2014-09-23, released 2015-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-10-28, with a file datestamp of 2015-10-23.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-End)
      • initiating methionine (1)
    Domains in SCOPe 2.08: d4whwa1, d4whwa2
  • Heterogens: 3OT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4whwA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >4whwA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpt