PDB entry 4w9h

View 4w9h on RCSB PDB site
Description: pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 7)
Class: ligase
Keywords: protein complex, ubiquitin ligase, hypoxia inducible factor, ligase
Deposited on 2014-08-27, released 2014-09-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-09-10, with a file datestamp of 2014-09-05.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.212
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Transcription elongation factor B polypeptide 2
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB2
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15370 (0-End)
• Chain 'B':
  Compound: Transcription elongation factor B polypeptide 1
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15369 (1-96)
• Chain 'C':
  Compound: von hippel-lindau disease tumor suppressor
  Species: Homo sapiens [TaxId:9606]
  Gene: VHL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P40337
  Domains in SCOPe 2.04: d4w9hc_
• Chain 'D':
  Compound: Transcription elongation factor B polypeptide 2
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB2
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15370 (0-End)
• Chain 'E':
  Compound: Transcription elongation factor B polypeptide 1
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15369 (1-96)
• Chain 'F':
  Compound: von hippel-lindau disease tumor suppressor
  Species: Homo sapiens [TaxId:9606]
  Gene: VHL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P40337
  Domains in SCOPe 2.04: d4w9hf_
• Chain 'G':
  Compound: Transcription elongation factor B polypeptide 2
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB2
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15370 (0-End)
• Chain 'H':
  Compound: Transcription elongation factor B polypeptide 1
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15369 (1-96)
• Chain 'I':
  Compound: von hippel-lindau disease tumor suppressor
  Species: Homo sapiens [TaxId:9606]
  Gene: VHL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P40337
  Domains in SCOPe 2.04: d4w9hi_
• Chain 'J':
  Compound: Transcription elongation factor B polypeptide 2
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB2
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15370 (0-End)
• Chain 'K':
  Compound: Transcription elongation factor B polypeptide 1
  Species: Homo sapiens [TaxId:9606]
  Gene: TCEB1
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q15369 (1-96)
    • initiating methionine (0)
• Chain 'L':
  Compound: von hippel-lindau disease tumor suppressor
  Species: Homo sapiens [TaxId:9606]
  Gene: VHL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P40337
  Domains in SCOPe 2.04: d4w9hl_
• Heterogens: 3JF, HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  Sequence, based on SEQRES records: (download)
  

  >4w9hC (C:)
  gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
  yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
  penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4w9hC (C:)
  vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
  agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
  rslyedledhpnvqkdlerlt
  

  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  Sequence, based on SEQRES records: (download)
  

  >4w9hF (F:)
  gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
  yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
  penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4w9hF (F:)
  vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
  agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
  rslyedledhpnvqkdlerltqer
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  Sequence, based on SEQRES records: (download)
  

  >4w9hI (I:)
  gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
  yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
  penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4w9hI (I:)
  vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
  agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
  rslyedledhpnvqkdlerltqe
  

  
  
• Chain 'J':
  No sequence available.
  
  
• Chain 'K':
  No sequence available.
  
  
• Chain 'L':
  Sequence, based on SEQRES records: (download)
  

  >4w9hL (L:)
  gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
  yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
  penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4w9hL (L:)
  vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
  agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
  rslyedledhpnvqkdlerltqe