PDB entry 4w9e

View 4w9e on RCSB PDB site
Description: pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 4)
Class: ligase
Keywords: protein complex, ubiquitin ligase, hypoxia inducible factor, transcription, ligase
Deposited on 2014-08-27, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-05, with a file datestamp of 2014-10-31.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.209
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transcription elongation factor B polypeptide 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ea_
  • Chain 'B':
    Compound: Transcription elongation factor B polypeptide 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9eb_
  • Chain 'C':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ec_
  • Chain 'D':
    Compound: Transcription elongation factor B polypeptide 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ed_
  • Chain 'E':
    Compound: Transcription elongation factor B polypeptide 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ee_
  • Chain 'F':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ef_
  • Chain 'G':
    Compound: Transcription elongation factor B polypeptide 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9eg_
  • Chain 'H':
    Compound: Transcription elongation factor B polypeptide 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9eh_
  • Chain 'I':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ei_
  • Chain 'J':
    Compound: Transcription elongation factor B polypeptide 2
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9ej_
  • Chain 'K':
    Compound: Transcription elongation factor B polypeptide 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d4w9ek1, d4w9ek2
  • Chain 'L':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w9el_
  • Heterogens: 3JT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4w9eA (A:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eA (A:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4w9eB (B:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eB (B:)
myvklissdghefivkrehaltsgtikamlsnevnfreipshvlskvcmyftykvrytns
steipefpiapeialellmaanfldc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4w9eC (C:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eC (C:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerlt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4w9eD (D:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eD (D:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafradtfealciepfssppelpdvm

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4w9eE (E:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eE (E:)
myvklissdghefivkrehaltsgtikamlsgtnevnfreipshvlskvcmyftykvryt
nssteipefpiapeialellmaanfldc

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4w9eF (F:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eF (F:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerltqer

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4w9eG (G:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eG (G:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvm

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4w9eH (H:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eH (H:)
myvklissdghefivkrehaltsgtikamlsgtnevnfreipshvlskvcmyftykvryt
nssteipefpiapeialellmaanfldc

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4w9eI (I:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eI (I:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerltqe

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4w9eJ (J:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eJ (J:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvm

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >4w9eK (K:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eK (K:)
mmyvklissdghefivkrehaltsgtikamlstnevnfreipshvlskvcmyftykvryt
nssteipefpiapeialellmaanfldc

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4w9eL (L:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >4w9eL (L:)
vlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfrd
agthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldiv
rslyedledhpnvqkdlerltqe