PDB entry 4w4o

View 4w4o on RCSB PDB site
Description: High-resolution crystal structure of Fc bound to its human receptor Fc-gamma-RI
Class: immune system
Keywords: immune complex IgG1 protein-protein complex asymmetry, IMMUNE SYSTEM
Deposited on 2014-08-15, released 2015-04-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-02.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • conflict (220)
    Domains in SCOPe 2.08: d4w4oa1, d4w4oa2
  • Chain 'B':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4w4ob1, d4w4ob2
  • Chain 'C':
    Compound: High affinity immunoglobulin gamma Fc receptor I
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGR1A, FCG1, FCGR1, IGFR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12314
      • engineered mutation (9)
      • engineered mutation (22)
      • engineered mutation (47)
      • engineered mutation (53)
      • engineered mutation (55)
      • engineered mutation (61-62)
      • engineered mutation (84)
      • engineered mutation (98)
      • engineered mutation (144)
      • engineered mutation (147)
      • engineered mutation (179)
      • engineered mutation (190-191)
      • engineered mutation (224)
  • Heterogens: ZN, ACT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4w4oA (A:)
htcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve
vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqp
repqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgs
fflyskltvdksrwqqgnvfscsvmhealhnhytqkslslapgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4w4oA (A:)
pellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkp
reeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytl
ppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflysklt
vdksrwqqgnvfscsvmhealhnhytqkslslapg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4w4oB (B:)
htcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgve
vhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqp
repqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgs
fflyskltvdksrwqqgnvfscsvmhealhnhytqkslslapgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4w4oB (B:)
lggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpree
qynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlpps
rdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdk
srwqqgnvfscsvmhealhnhytqkslsl

  • Chain 'C':
    No sequence available.