PDB entry 4uxn

View 4uxn on RCSB PDB site
Description: LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580
Class: oxidoreductase
Keywords: oxidoreductase, covalent inhibitor, tranylcypromine
Deposited on 2014-08-27, released 2015-02-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.20633
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4uxna1, d4uxna2, d4uxna3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4uxnb1, d4uxnb2
  • Heterogens: FAD, M8A

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4uxnA (A:)
    mlsgkkaaaaaaaaaaaatgteagpgtaggsengsevaaqpaglsgpaevgpgavgertp
    rkkepprasppgglaeppgsagpqagptvvpgsatpmetgiaetpegrrtsrrkrakvey
    remdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgvegaafq
    srlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfeatlqqlea
    pynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsglaaarqlqsf
    gmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnmelakikqkc
    plyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqalevviqlqe
    khvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkpprditaeflv
    kskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwhfanlefan
    atplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrqvrytasgc
    eviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavqrmgfgnln
    kvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaagimenisd
    dvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgndydlmaqpi
    tpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflgamytlprqa
    tpgvpaqqspsm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uxnA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamytl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4uxnB (B:)
    mvekgpevsgkrrgrnnaaasasaaaasaaasaacaspaataasgaaassasaaaasaaa
    apnngqnkslaaaapngnsssnsweegssgsssdeehggggmrvgpqyqavvpdfdpakl
    arrsqerdnlgmlvwspnqnlseakldeyiaiakekhgynmeqalgmlfwhkhnieksla
    dlpnftpfpdewtvedkvlfeqafsfhgktfhriqqmlpdksiaslvkfyyswkktrtkt
    svmdrharkqkrereesedeleeangnnpidievdqnkeskkevpptetvpqvkkekhst
    qaknrakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalk
    ekldggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknf
    fvnyrrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryas
    as
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uxnB (B:)
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweae