PDB entry 4uvc

View 4uvc on RCSB PDB site
Description: LSD1(KDM1A)-CoREST in complex with 1-Phenyl-Tranylcypromine
Class: transcription
Keywords: transcription, histone demethylase
Deposited on 2014-08-05, released 2014-09-10
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-09-10, with a file datestamp of 2014-09-05.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.21094
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1A
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60341
      • conflict (190)
    Domains in SCOPe 2.05: d4uvca1, d4uvca2, d4uvca3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4uvcb1, d4uvcb2
  • Heterogens: D52

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4uvcA (A:)
    mlsgkkaaaaaaaaaaaatgteagpgtaggsengsevaaqpaglsgpaevgpgavgertp
    rkkepprasppgglaeppgsagpqagptvvpgsatpmetgiaetpegrrtsrrkrakvey
    remdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgqagglqd
    dssggygdgqpsgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlql
    wldnpkiqltfeatlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgk
    viiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggn
    pmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnv
    lnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhq
    qykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvy
    lssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalae
    gldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfv
    pplpewktsavqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlyka
    pillalvageaagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargs
    ysyvaagssgndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglr
    eagriadqflgamytlprqatpgvpaqqspsm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uvcA (A:)
    psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
    featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
    laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
    melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
    alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
    prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
    whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
    rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
    vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
    aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
    ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
    gamytl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4uvcB (B:)
    mvekgpevsgkrrgrnnaaasasaaaasaaasaacaspaataasgaaassasaaaasaaa
    apnngqnkslaaaapngnsssnsweegssgsssdeehggggmrvgpqyqavvpdfdpakl
    arrsqerdnlgmlvwspnqnlseakldeyiaiakekhgynmeqalgmlfwhkhnieksla
    dlpnftpfpdewtvedkvlfeqafsfhgktfhriqqmlpdksiaslvkfyyswkktrtkt
    svmdrharkqkrereesedeleeangnnpidievdqnkeskkevpptetvpqvkkekhst
    qaknrakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalk
    ekldggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknf
    fvnyrrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryas
    as
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uvcB (B:)
    rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
    epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
    fnidevlqeweae