PDB entry 4uva

View 4uva on RCSB PDB site
Description: LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S)
Class: transcription
Keywords: transcription, covalent inhibitor
Deposited on 2014-08-05, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-10, with a file datestamp of 2014-09-05.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.22036
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60341
      • conflict (190)
    Domains in SCOPe 2.08: d4uvaa1, d4uvaa2, d4uvaa3
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uvab1, d4uvab2
  • Heterogens: D73, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4uvaA (A:)
mlsgkkaaaaaaaaaaaatgteagpgtaggsengsevaaqpaglsgpaevgpgavgertp
rkkepprasppgglaeppgsagpqagptvvpgsatpmetgiaetpegrrtsrrkrakvey
remdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgqagglqd
dssggygdgqpsgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlql
wldnpkiqltfeatlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgk
viiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggn
pmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnv
lnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhq
qykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvy
lssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalae
gldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfv
pplpewktsavqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlyka
pillalvageaagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargs
ysyvaagssgndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglr
eagriadqflgamytlprqatpgvpaqqspsm

    Sequence, based on observed residues (ATOM records): (download) 
    >4uvaA (A:)
psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
gamytl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4uvaB (B:)
mvekgpevsgkrrgrnnaaasasaaaasaaasaacaspaataasgaaassasaaaasaaa
apnngqnkslaaaapngnsssnsweegssgsssdeehggggmrvgpqyqavvpdfdpakl
arrsqerdnlgmlvwspnqnlseakldeyiaiakekhgynmeqalgmlfwhkhnieksla
dlpnftpfpdewtvedkvlfeqafsfhgktfhriqqmlpdksiaslvkfyyswkktrtkt
svmdrharkqkrereesedeleeangnnpidievdqnkeskkevpptetvpqvkkekhst
qaknrakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalk
ekldggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknf
fvnyrrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryas
as

    Sequence, based on observed residues (ATOM records): (download) 
    >4uvaB (B:)
rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
fnidevlqeweae