PDB entry 4uta

View 4uta on RCSB PDB site
Description: Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8
Class: immune system-viral protein complex
Keywords: immune system-viral protein complex, viral protein, membrane fusion, class 2 fusion protein, dengue virus, broadly neutralizing antibody
Deposited on 2014-07-18, released 2015-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: envelope glycoprotein E
    Species: DENGUE VIRUS 2 [TaxId:11060]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q68Y26 (0-390)
      • expression tag (391-394)
      • conflict (117)
    Domains in SCOPe 2.08: d4utaa1, d4utaa2, d4utaa3
  • Chain 'B':
    Compound: envelope glycoprotein E
    Species: DENGUE VIRUS 2 [TaxId:11060]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q68Y26 (0-390)
      • expression tag (391-397)
      • conflict (117)
    Domains in SCOPe 2.08: d4utab1, d4utab2, d4utab3
  • Chain 'H':
    Compound: broadly neutralizing human antibody ede1 c8 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4UTA
  • Chain 'I':
    Compound: broadly neutralizing human antibody ede1 c8 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4UTA
  • Chain 'L':
    Compound: broadly neutralizing human antibody ede1 c8 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4UTA
    Domains in SCOPe 2.08: d4utal1, d4utal2
  • Chain 'M':
    Compound: broadly neutralizing human antibody ede1 c8 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4UTA
    Domains in SCOPe 2.08: d4utam1, d4utam2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4utaA (A:)
mrcigisnrdfvegvsggswvdivlehgscvttmaknkptldfelikteakqpatlrkyc
ieakltntttesrcptqgepslneeqdkrfickhsmvdrgwgngcglfgkggivtcakft
ckknmegkivqpenleytivitphsgeehavgndtgkhgkeikitpqsstteaeltgygt
vtmecsprtgldfnemvllqmedkawlvhrqwfldlplpwlpgadtqgsnwiqketlvtf
knphakkqdvvvlgsqegamhtaltgateiqmssgnllftghlkcrlrmdklqlkgmsys
mctgkfkivkeiaetqhgtivirvqyegdgspckipfeitdlekrhvlgrlitvnpivte
kdspvnieaeppfgdsyiivgvepgqlklnwlrplesrgpfegkpipnpllgldstrtgh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4utaA (A:)
mrcigisnrdfvegvsggswvdivlehgscvttmaknkptldfelikteakqpatlrkyc
ieakltntttesrcptqgepslneeqdkrfickhsmvdrgwgngcglfgkggivtcakft
ckknmegkivqpenleytivitphsgeehkhgkeikitpqsstteaeltgygtvtmecsp
rtgldfnemvllqmedkawlvhrqwfldlplpwlpgadtqgsnwiqketlvtfknphakk
qdvvvlgsqegamhtaltgateiqmssgnllftghlkcrlrmdklqlkgmsysmctgkfk
ivkeiaetqhgtivirvqgspckipfeitdvlgrlitvnpivtekdspvnieaeppfgds
yiivlklnwlrpl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4utaB (B:)
mrcigisnrdfvegvsggswvdivlehgscvttmaknkptldfelikteakqpatlrkyc
ieakltntttesrcptqgepslneeqdkrfickhsmvdrgwgngcglfgkggivtcakft
ckknmegkivqpenleytivitphsgeehavgndtgkhgkeikitpqsstteaeltgygt
vtmecsprtgldfnemvllqmedkawlvhrqwfldlplpwlpgadtqgsnwiqketlvtf
knphakkqdvvvlgsqegamhtaltgateiqmssgnllftghlkcrlrmdklqlkgmsys
mctgkfkivkeiaetqhgtivirvqyegdgspckipfeitdlekrhvlgrlitvnpivte
kdspvnieaeppfgdsyiivgvepgqlklnwlrplesrgpfegkpipnpllgldstrtgh
hhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4utaB (B:)
mrcigisnrdfvegvsggswvdivlehgscvttmaknkptldfelikteakqpatlrkyc
ieakltntttesrcptqgepslneeqdkrfickhsmvdrgwgngcglfgkggivtcakft
ckknmegkivqpenleytivitphsgeehhgkeikitpqsstteaeltgygtvtmecspr
tgldfnemvllqmedkawlvhrqwfldlplpwlpgadtqgsnwiqketlvtfknphakkq
dvvvlgsqegamhtaltgateiqmssgnllftghlkcrlrmdklqlkgmsysmctgkfki
vkeiaetqhgtivirvqyegdgspckipfeikrhvlgrlitvnpivtekdspvnieaepp
fgdsyiivgvepgqlklnwlrplesr

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4utaL (L:)
rseivltqspatlslspgeratlscrasqsistflawyqhkpgqaprlliydastratgv
parfsgsrsgtdftltistlepedfavyycqqrynwppytfgqgtkveikrtvaapsvfi
fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
tltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4utaL (L:)
seivltqspatlslspgeratlscrasqsistflawyqhkpgqaprlliydastratgvp
arfsgsrsgtdftltistlepedfavyycqqrynwppytfgqgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >4utaM (M:)
rseivltqspatlslspgeratlscrasqsistflawyqhkpgqaprlliydastratgv
parfsgsrsgtdftltistlepedfavyycqqrynwppytfgqgtkveikrtvaapsvfi
fppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslss
tltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4utaM (M:)
seivltqspatlslspgeratlscrasqsistflawyqhkpgqaprlliydastratgvp
arfsgsrsgtdftltistlepedfavyycqqrynwppytfgqgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge