PDB entry 4uqi

View 4uqi on RCSB PDB site
Description: AP2 controls clathrin polymerization with a membrane-activated switch
Class: endocytosis
Keywords: endocytosis, protein transport, lipid binding
Deposited on 2014-06-23, released 2014-07-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-08-06, with a file datestamp of 2014-08-01.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: 0.20573
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ap-2 complex subunit alpha-2
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18484
      • insertion (271)
    Domains in SCOPe 2.06: d4uqia_
  • Chain 'B':
    Compound: ap-2 complex subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: ap-2 complex subunit mu
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: ap-2 complex subunit sigma
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4uqis_
  • Heterogens: CL, IHP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4uqiA (A:)
mpavskgdgmrglavfisdirnckskeaeikrinkelanirskfkgdkaldgyskkkyvc
kllfifllghdidfghmeavnllssnrytekqigylfisvlvnsnselirlinnaikndl
asrnptfmglalhcianvgsremaeafageipkilvagdtmdsvkqsaalcllrlyrtsp
dlvpmgdwtsrvvhllndqhlgvvtaatslittlaqknpeefktsvslavsrlsrivtsa
stdlqdytyyfvpapwlsvkllrllqcypppedpavrgrltecletilnkaqeppkskkv
qhsnaknavlfeaisliihhdsepnllvracnqlgqflqhretnlrylalesmctlasse
fsheavkthietvinalkterdvsvrqravdllyamcdrsnaqqivaemlsyletadysi
reeivlkvailaekyavdytwyvdtilnliriagdyvseevwyrviqivinrddvqgyaa
ktvfealqapachenlvkvggyilgefgnliagdprsspliqfnllhskfhlcsvptral
llstyikfvnlfpevkatiqdvlrsdsqlknadvelqqraveylrlstvastdilatvle
emppfperessilaklkkkkggsglvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >4uqiA (A:)
gmrglavfisdirnckskeaeikrinkelanirskfkgdkaldgyskkkyvckllfifll
ghdidfghmeavnllssnrytekqigylfisvlvnsnselirlinnaikndlasrnptfm
glalhcianvgsremaeafageipkilvagdtmdsvkqsaalcllrlyrtspdlvpmgdw
tsrvvhllndqhlgvvtaatslittlaqknpeefktsvslavsrlsrivtsastdlqdyt
yyfvpapwlsvkllrllqcypppedpavrgrltecletilnkaqeppkskkvqhsnakna
vlfeaisliihhdsepnllvracnqlgqflqhretnlrylalesmctlassefsheavkt
hietvinalkterdvsvrqravdllyamcdrsnaqqivaemlsyletadysireeivlkv
ailaekyavdytwyvdtilnliriagdyvseevwyrviqivinrddvqgyaaktvfealq
apachenlvkvggyilgefgnliagdprsspliqfnllhskfhlcsvptralllstyikf
vnlfpevkatiqdvlrsdsqlknadvelqqraveylrlstvastdilatvleemppfper

  • Chain 'B':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4uqiS (S:)
mirfiliqnragktrlakwymqfdddekqklieevhavvtvrdakhtnfvefrnfkiiyr
ryaglyfcicvdvndnnlayleaihnfvevlneyfhnvceldlvfnfykvytvvdemfla
geiretsqtkvlkqllmlqsle