PDB entry 4ui2

View 4ui2 on RCSB PDB site
Description: Crystal structure of the ternary RGMB-BMP2-NEO1 complex
Class: signaling protein
Keywords: repulsive guidance molecule, bone morphogenetic protein pathway, hemojuvelin, morphogen, axon guidance, cell surface receptor signaling, neogenin, signaling protein
Deposited on 2015-03-27, released 2015-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neogenin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: bone morphogenetic protein 2, bmp2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ui2b_
  • Chain 'C':
    Compound: repulsive guidance molecule c, rgmc, hemojuvelin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: repulsive guidance molecule c, rgmc, hemojuvelin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6NW40 (0-End)
      • conflict (56)
  • Heterogens: SRT, ACT

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4ui2B (B:)
    qakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnh
    aivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ui2B (B:)
    kssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsv
    nskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.