PDB entry 4u5w

View 4u5w on RCSB PDB site
Description: Crystal Structure of HIV-1 Nef-SF2 Core Domain in Complex with the Src Family Kinase Hck SH3-SH2 Tandem Regulatory Domains
Class: Viral protein/Transferase
Keywords: Hck, SH3-SH2 regulatory domains, SH3, SH2, Src Family Kinase, SFK, HIV-1, Nef, virus, protein-protein complex, Nef-Hck complex, viral protein-transferase complex
Deposited on 2014-07-25, released 2014-08-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.17
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein Nef
    Species: Human immunodeficiency virus type 1 [TaxId:11685]
    Gene: nef
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4u5wa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Gene: HCK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4u5wb1
  • Chain 'C':
    Compound: Protein Nef
    Species: Human immunodeficiency virus type 1 [TaxId:11685]
    Gene: nef
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4u5wc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase HCK
    Species: Homo sapiens [TaxId:9606]
    Gene: HCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08631 (Start-171)
      • expression tag (172-173)
    Domains in SCOPe 2.06: d4u5wd1, d4u5wd2, d4u5wd3
  • Heterogens: MPD, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4u5wA (A:)
    mleaqeeeevgfpvrpqvplrpmtykaaldishflkekgglegliwsqrrqeildlwiyh
    tqgyfpdwqnytpgpgirypltfgwcfklvpvepekveeanegennsllhpmslhgmeda
    ekevlvwrfdsklafhhmarelhpeyykd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4u5wA (A:)
    fpvrpqvplrpmtykaaldishflkekgglegliwsqrrqeildlwiyhtqgyfpdwqny
    tpgpgirypltfgwcfklvpvepekveeanevlvwrfdsklafhhmarelhpeyyk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4u5wB (B:)
    mgireagsediivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyips
    nyvarvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydpr
    qgdtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4u5wB (B:)
    diivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
    eteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhyk
    irtldnggfyisprstfstlqelvdhykkgndglcqklsvpcm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4u5wC (C:)
    mleaqeeeevgfpvrpqvplrpmtykaaldishflkekgglegliwsqrrqeildlwiyh
    tqgyfpdwqnytpgpgirypltfgwcfklvpvepekveeanegennsllhpmslhgmeda
    ekevlvwrfdsklafhhmarelhpeyykd
    

    Sequence, based on observed residues (ATOM records): (download)
    >4u5wC (C:)
    gfpvrpqvplrpmtykaaldishflkekgglegliwsqrrqeildlwiyhtqgyfpdwqn
    ytpgpgirypltfgwcfklvpvepkevlvwrfdsklafhhmarelhpeyyk
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4u5wD (D:)
    mgireagsediivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyips
    nyvarvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydpr
    qgdtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4u5wD (D:)
    diivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarvdsl
    eteewffkgisrkdaerqllapgnmlgsfmirdgsyslsvrdydprqgdtvkhykirtld
    nggfyisprstfstlqelvdhykkgndglcqklsvpcmle