PDB entry 4u3b

View 4u3b on RCSB PDB site
Description: LpxC from A.Aaeolicus in complex with the MMP inhibitor 4-[[4-(4-chlorophenoxy)phenyl]sulfanylmethyl]tetrahydropyran-4-carbohydroxamic acid - compound 2
Class: hydrolase
Keywords: antibacterial, lpxc, gram negative bacteria, MMP, hydrophobe, HYDROLASE
Deposited on 2014-07-19, released 2014-10-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 1.34 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
    Species: Aquifex aeolicus [TaxId:224324]
    Gene: lpxC, envA, aq_1772
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67648
      • conflict (180)
    Domains in SCOPe 2.08: d4u3ba1, d4u3ba2
  • Heterogens: IMD, ZN, CL, 3BW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4u3bA (A:)
mglektvkeklsfegvgihtgeyskliihpekegtgirffkngvyiparhefvvhtnhst
dlgfkgqriktvehilsvlhlleitnvtievigneipildgsgwefyeairknilnqnre
idyfvveepiivedegrlikaepsdtlevtyegefknflgrqkftfvegneeeivlartf
afdweiehikkvglgkggslkntlvlgkdkvynpeglryenepvrhkvfdligdlyllgs
pvkgkfysfrgghslnvklvkelakkqkltr

    Sequence, based on observed residues (ATOM records): (download) 
    >4u3bA (A:)
glektvkeklsfegvgihtgeyskliihpekegtgirffkngvyiparhefvvhtnhstd
lgfkgqriktvehilsvlhlleitnvtievigneipildgsgwefyeairknilnqnrei
dyfvveepiivedegrlikaepsdtlevtyegefknflgrqkftfvegneeeivlartfa
fdweiehikkvglgkggslkntlvlgkdkvynpeglryenepvrhkvfdligdlyllgsp
vkgkfysfrgghslnvklvkelakkqk