PDB entry 4u0i

View 4u0i on RCSB PDB site
Description: Crystal structure of KIT in complex with ponatinib
Class: transferase/transferase inhibitor
Keywords: KIT, receptor tyrosine kinase, inhibitor, ponatinib, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-07-11, released 2014-10-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4u0ia_
  • Heterogens: 0LI, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4u0iA (A:)
ingnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvav
kmlkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnfl
rrkrdsficsktspaimeddelaldledllsfsyqvakgmaflaskncihrdlaarnill
thgritkicdfglardikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflw
elfslgsspypgmpvdskfykmikegfrmlspehapaemydimktcwdadplkrptfkqi
vqliekqisestnhi

    Sequence, based on observed residues (ATOM records): (download) 
    >4u0iA (A:)
gnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliaamtvavkmlkp
sahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrrkrd
sficslaldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdfglard
ikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspypgmpvd
skfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqisestn