PDB entry 4tyg

View 4tyg on RCSB PDB site
Description: Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase
Class: transferase
Keywords: Fibroblast growth factor receptor, Kinase, Transferase, Dovitinib, Ponatinb, Proteros Biostructures GmbH
Deposited on 2014-07-08, released 2014-09-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-12-10, with a file datestamp of 2014-12-05.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.204
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 4
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR4, JTK2, TKF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22455 (4-End)
      • expression tag (1-3)
    Domains in SCOPe 2.05: d4tyga_
  • Heterogens: ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4tygA (A:)
amgsaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdparpdqastvav
kmlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlrefl
rarrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvte
dnvmkiadfglargvhhidyykktsngrlpvkwmapealfdrvythqsdvwsfgillwei
ftlggspypgipveelfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvea
ldkvllavsee

    Sequence, based on observed residues (ATOM records): (download) 
    >4tygA (A:)
mgsaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdparpdqastvavk
mlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflr
arrpplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfglargvh
hidyykktsngrlpvkwmapealfdrvythqsdvwsfgillweiftlggspypgipveel
fsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvealdkvllavs