PDB entry 4twp

View 4twp on RCSB PDB site
Description: The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib
Class: Transferase/Transferase Inhibitor
Keywords: gatekeeper mutant Kinase domain DFGin, Transferase-Transferase Inhibitor complex
Deposited on 2014-07-01, released 2015-02-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-03-04, with a file datestamp of 2015-02-27.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1, ABL, JTK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00519 (0-270)
      • engineered mutation (82)
    Domains in SCOPe 2.05: d4twpa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1, ABL, JTK7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00519 (0-270)
      • engineered mutation (82)
    Domains in SCOPe 2.05: d4twpb_
  • Heterogens: AXI, NI, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4twpA (A:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatqissame
ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
racwqwnpsdrpsfaeihqafetmfqessis

    Sequence, based on observed residues (ATOM records): (download) 
    >4twpA (A:)
dkwemertditmkhklgggqygevyegvwkkysltvavktleveeflkeaavmkeikhpn
lvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatqissameylekk
nfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfs
iksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwq
wnpsdrpsfaeihqafetmfqessis

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4twpB (B:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevnavvllymatqissame
ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
racwqwnpsdrpsfaeihqafetmfqessis