PDB entry 4tvj

View 4tvj on RCSB PDB site
Description: human artd2 (parp2) - catalytic domain in complex with olaparib
Class: transferase
Keywords: Poly(ADP-Ribose) transferase, Inhibitor, ADP-Ribosylation, TRANSFERASE
Deposited on 2014-06-27, released 2015-07-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-07-08, with a file datestamp of 2015-07-02.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP2, ADPRT2, ADPRTL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGN5 (23-367)
      • expression tag (11-22)
      • conflict (235)
    Domains in SCOPe 2.06: d4tvja1, d4tvja2, d4tvja3
  • Chain 'B':
    Compound: Poly [ADP-ribose] polymerase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: PARP2, ADPRT2, ADPRTL2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGN5 (23-367)
      • expression tag (14-22)
      • conflict (235)
    Domains in SCOPe 2.06: d4tvjb1, d4tvjb2, d4tvjb3
  • Heterogens: 09L, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4tvjA (A:)
mhhhhhhssgvdlgtenlyfqsmdlrvqeliklicnvqameemmmemkyntkkaplgklt
vaqikagyqslkkiedciragqhgralmeacnefytriphdfglrtpplirtqkelseki
qllealgdieiaiklvktelqspehpldqhyrnlhcalrpldhesyefkvisqylqstha
pthsdytmtlldlfevekdgekeafredlhnrmllwhgsrmsnwvgilshglriahpeap
itgymfgkgiyfadmssksanycfasrlkntgllllsevalgqcnelleanpkaegllqg
khstkglgkmapssahfvtlngstvplgpasdtgilnpdgytlnyneyivynpnqvrmry
llkvqfnf

    Sequence, based on observed residues (ATOM records): (download) 
    >4tvjA (A:)
dlgtenlyfqsmdlrvqeliklicnvqameemmmemkyntkkaplgkltvaqikagyqsl
kkiedciragqhgralmeacnefytriphdfglrtpplirtqkelsekiqllealgdiei
aiklvktelqspehpldqhyrnlhcalrpldhesyefkvisqylqsthapthsdytmtll
dlfevekdgekeafredlhnrmllwhgsrmsnwvgilshglriahpeapitgymfgkgiy
fadmssksanycfasrlkntgllllsevalgqcnelleanpkaegllqgkhstkglgkma
pssahfvtlngstvplgpasdtgilnpdgytlnyneyivynpnqvrmryllkvqfnf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4tvjB (B:)
mhhhhhhssgvdlgtenlyfqsmdlrvqeliklicnvqameemmmemkyntkkaplgklt
vaqikagyqslkkiedciragqhgralmeacnefytriphdfglrtpplirtqkelseki
qllealgdieiaiklvktelqspehpldqhyrnlhcalrpldhesyefkvisqylqstha
pthsdytmtlldlfevekdgekeafredlhnrmllwhgsrmsnwvgilshglriahpeap
itgymfgkgiyfadmssksanycfasrlkntgllllsevalgqcnelleanpkaegllqg
khstkglgkmapssahfvtlngstvplgpasdtgilnpdgytlnyneyivynpnqvrmry
llkvqfnf

    Sequence, based on observed residues (ATOM records): (download) 
    >4tvjB (B:)
tenlyfqsmdlrvqeliklicnvqameemmmemkyntkkaplgkltvaqikagyqslkki
edciragqhgralmeacnefytriphdfglrtpplirtqkelsekiqllealgdieiaik
lvktspehpldqhyrnlhcalrpldhesyefkvisqylqsthapthsdytmtlldlfeve
kdgekeafredlhnrmllwhgsrmsnwvgilshglriahpeapitgymfgkgiyfadmss
ksanycfasrlkntgllllsevalgqcnelleanpkaegllqgkhstkglgkmapssahf
vtlngstvplgpasdtgilnpdgytlnyneyivynpnqvrmryllkvqfnf