PDB entry 4tth

View 4tth on RCSB PDB site
Description: Crystal structure of a CDK6/Vcyclin complex with inhibitor bound
Class: transferase/cell cycle/inhibitor
Keywords: Kinase, TRANSFERASE-CELL CYCLE-INHIBITOR complex
Deposited on 2014-06-20, released 2014-08-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin homolog
    Species: Saimiriine herpesvirus 2 [TaxId:10383]
    Gene: 72, ECLF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ttha1, d4ttha2
  • Chain 'B':
    Compound: cyclin-dependent kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK6, CDKN6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4tthb_
  • Heterogens: 24V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4tthA (A:)
madspnrlnrakidsttmkdprvlnnlklrelllpkftslweiqtevtvdnrtilltwmh
llcesfeldksvfplsvsildrylckkqgtkktlqkigaacvligskirtvkpmtvsklt
ylscdcftnlelinqekdilealkwdteavlatdfliplcnalkipedlwpqlyeaastt
ickaliqpniallspglicaggllttietdntncrpwtcyledlssilnfstntvrtvkd
qvseafslydleil

    Sequence, based on observed residues (ATOM records): (download) 
    >4tthA (A:)
lnrakidsttmkdprvlnnlklrelllpkftslweiqtevtvdnrtilltwmhllcesfe
ldksvfplsvsildrylckkqgtkktlqkigaacvligskirtvkpmtvskltylsftnl
elinqekdilealkwdteavlatdfliplcnalkipedlwpqlyeaasttickaliqpni
allspglicaggllttietdntncrpwtcyledlssilnfstntvrtvkdqvseafslyd
leil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4tthB (B:)
mekdglcradqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstir
evavlrhletfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvpte
tikdmmfqllrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvv
vtlwyrapevllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpge
edwprdvalprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyf
qdlerckenldshlppsqntselnta

    Sequence, based on observed residues (ATOM records): (download) 
    >4tthB (B:)
cvaeigekvfkardlkngrfvalkrvrvegmplstirevavlrhletfehpnvvrlfdvc
ttkltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgldflhshrvvhrdlkpqn
ilvtssgqikladfglariysfqmaltsvvvtlwyrapevllqssyatpvdlwsvgcifa
emfrrkplfrgssdvdqlgkildviglpgeedwppiekfdidelgkdlllkcltfnpakr
isaysalshpyfqdle