PDB entry 4tqb

View 4tqb on RCSB PDB site
Description: The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Class: protein binding
Keywords: eIF4E, translation initiation inhibitor, allosteric, 4EGI1, PROTEIN BINDING
Deposited on 2014-06-10, released 2014-08-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-01, with a file datestamp of 2014-09-26.
Experiment type: XRAY
Resolution: 1.59 Å
R-factor: 0.183
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: eukaryotic translation initiation factor 4e
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF4E, EIF4EL1, EIF4F
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4tqba_
  • Chain 'B':
    Compound: eukaryotic translation initiation factor 4e
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF4E, EIF4EL1, EIF4F
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4tqbb_
  • Heterogens: MGT, 34K, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4tqbA (A:)
mvanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlm
pgcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddys
ddvcgavvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatk
sgsttknrfvv

    Sequence, based on observed residues (ATOM records): (download) 
    >4tqbA (A:)
hyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmpgcdys
lfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvcga
vvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatksgsttk
nrfvv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4tqbB (B:)
mvanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlm
pgcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddys
ddvcgavvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatk
sgsttknrfvv

    Sequence, based on observed residues (ATOM records): (download) 
    >4tqbB (B:)
ikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmpgcdyslf
kdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvcgavv
nvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatksgsttknr
fvv