PDB entry 4tmf

View 4tmf on RCSB PDB site
Description: Crystal structure of human CD38 in complex with hydrolysed compound JMS713
Class: Hydrolase/Hydrolase Inhibitor
Keywords: CD38, ADP-ribosyl cyclase, cyclic ADP-ribose, X-crystallography, Calcium signaling, inhibitory compound, JMS713, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2014-06-01, released 2015-05-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • expression tag (4-5)
      • engineered mutation (56)
      • engineered mutation (120)
      • engineered mutation (165)
      • engineered mutation (175)
    Domains in SCOPe 2.07: d4tmfa1, d4tmfa2
  • Chain 'B':
    Compound: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • expression tag (0-5)
      • engineered mutation (56)
      • engineered mutation (120)
      • engineered mutation (165)
      • engineered mutation (175)
    Domains in SCOPe 2.07: d4tmfb1, d4tmfb2
  • Heterogens: JS2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4tmfA (A:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4tmfA (A:)
qtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditeedyq
plmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefdtsk
inyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgsvev
hnlqpekvqtleawvihgrdlcqdptikelesiiskrniqfsckniyrpdkflqcvknpe
dssc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4tmfB (B:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4tmfB (B:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihrdlcqdptikelesiiskrniqfsckniyrpdkflqcvk
np