PDB entry 4s1q

View 4s1q on RCSB PDB site
Description: Crystal structure of a VRC01-lineage antibody, 45-VRC01.H03+06.D-001739, in complex with clade A/E HIV-1 gp120 core
Class: viral protein/immune system
Keywords: HIV-1, neutralizing antibodies, VRC01-lineage, antibody maturation, evolutionary rate, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2015-01-14, released 2015-04-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'G':
    Compound: HIV-1 gp120 core
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: HIV-1 ENV
    Database cross-references and differences (RAF-indexed):
    • PDB 4S1Q (0-352)
  • Chain 'H':
    Compound: Fab of VRC01-lineage antibody,45-VRC01.H03+06.D-001739 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: Heavy chain
    Database cross-references and differences (RAF-indexed):
    • PDB 4S1Q (0-End)
    Domains in SCOPe 2.08: d4s1qh_
  • Chain 'L':
    Compound: Fab of VRC01 light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: Light chain
    Database cross-references and differences (RAF-indexed):
    • PDB 4S1Q (0-End)
    Domains in SCOPe 2.08: d4s1ql1, d4s1ql2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4s1qH (H:)
evrliqsgavmrkpgssvkiscrasgynfreysihwvrlipgrglewigwikgmwgavsy
arqlqgrvsmtrqlsqdpddpdwgiaylefsgltsgdtaeyfcvrkgpscphcgdfhwqh
wgqgtavvvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsg
vhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >4s1qH (H:)
evrliqsgavmrkpgssvkiscrasgynfreysihwvrlipgrglewigwikgmwgavsy
arqlqgrvsmtrqlsqdpddpdwgiaylefsgltsgdtaeyfcvrkgpscphcgdfhwqh
wgqgtavvvsaastkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4s1qL (L:)
eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrf
sgsrwgpdytltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifppsdeq
lksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltlska
dyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >4s1qL (L:)
eivltqspgtlslspgetaiiscrtsqygslawyqqrpgqaprlviysgstraagipdrf
sgsrwgpdytltisnlesgdfgvyycqqyeffgqgtkvqvdikrtvaapsvfifppsdeq
lksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltlska
dyekhkvyacevthqglsspvtksfnrge