PDB entry 4ryz

View 4ryz on RCSB PDB site
Description: Crystal structure of RPE65 in complex with S-emixustat and palmitate
Class: isomerase
Keywords: 7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, ISOMERASE
Deposited on 2014-12-17, released 2015-05-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-05-27, with a file datestamp of 2015-05-22.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (Start-531)
      • conflict (339)
    Domains in SCOPe 2.06: d4ryza_
  • Chain 'B':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (Start-531)
      • conflict (339)
    Domains in SCOPe 2.06: d4ryzb_
  • Heterogens: FE2, PLM, A5V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ryzA (A:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrffs
yfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahp
hiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyvh
sfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyin
nkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarkap
qpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpqi
nyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdalee
ddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >4ryzA (A:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpevtdnalvniyp
vgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfia
ynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfk
flsswslwganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedhef
livdlccwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknl
vtlpnttatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfv
pdrlcklnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayll
ilnakdlsevaraeveinipvtfhglfkks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ryzB (B:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrffs
yfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahp
hiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyvh
sfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyin
nkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarkap
qpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpqi
nyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdalee
ddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >4ryzB (B:)
ssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlf
dgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpevtdnalvniyp
vgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfia
ynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfk
flsswslwganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedhef
livdlccwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknl
vtlpnttatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfv
pdrlcklnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayll
ilnakdlsevaraeveinipvtfhglfkks