PDB entry 4rx0

View 4rx0 on RCSB PDB site
Description: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: alpha/beta barrel, oxidoreductase, FM, mitochondrial membrane, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2014-12-08, released 2015-07-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: dihydroorotate dehydrogenase, PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4rx0a_
  • Heterogens: D65, FMN, ORO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rx0A (A:)
mghhhhhhaenlyfqgadpfesynpefflydiflkfclkyidgeichdlflllgkynilp
ydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgn
akprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdt
vnivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknn
imndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqindiks
fenkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasvcqly
sclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >4rx0A (A:)
ynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfinp
fgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgfnn
mgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryadyia
invsspeagklkniilsvkeeidnleknnimndeflwfnttkkkplvfvklapdlnqeqk
keiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytnkq
ipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyynlk
eaigrkh