PDB entry 4rwj

View 4rwj on RCSB PDB site
Description: Crystal Structure of FGFR1 (C488A, C584S) in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE)
Class: transferase/transferase inhibitor
Keywords: receptor tyrosine kinase, kinase, proto-oncogene, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-12-04, released 2015-04-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.49 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (9-End)
      • expression tag (8)
      • engineered mutation (39)
      • engineered mutation (135)
    Domains in SCOPe 2.08: d4rwja1, d4rwja2
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (39)
    Domains in SCOPe 2.08: d4rwjb_
  • Heterogens: 66T, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rwjA (A:)
mghhhhhhmagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrv
tkvavkmlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgn
lreylqarrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarn
vlvtednvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgv
llweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfk
qlvedldrivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4rwjA (A:)
magvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
mkiadfglardihhidyykktngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
valtsnq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rwjB (B:)
mghhhhhhmagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrv
tkvavkmlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgn
lreylqarrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarn
vlvtednvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgv
llweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfk
qlvedldrivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4rwjB (B:)
gvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlks
datekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrp
pgqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglykkttgr
lpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdk
psnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn