PDB entry 4rwi

View 4rwi on RCSB PDB site
Description: Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo
Class: transferase/transferase inhibitor
Keywords: receptor tyrosine kinase, gatekeeper mutation, proto-oncogene, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-12-04, released 2015-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.29 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (39)
      • engineered mutation (112)
      • engineered mutation (135)
    Domains in SCOPe 2.08: d4rwia_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (112)
    Domains in SCOPe 2.08: d4rwib_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rwiA (A:)
mghhhhhhmagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrv
tkvavkmlksdatekdlsdlisememmkmigkhkniinllgactqdgplyvimeyaskgn
lreylqarrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarn
vlvtednvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgv
llweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfk
qlvedldrivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4rwiA (A:)
vseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksd
atekdlsdlisememmkmigkhkniinllgactqdgplyvimeyaskgnlreylqarrpp
gleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmki
adfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggs
pypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldriva
ltsnq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rwiB (B:)
mghhhhhhmagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrv
tkvavkmlksdatekdlsdlisememmkmigkhkniinllgactqdgplyvimeyaskgn
lreylqarrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarn
vlvtednvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgv
llweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfk
qlvedldrivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4rwiB (B:)
seyelpedprwelprdrlvlgkplgeggqvvlaeaigldkdkpnrvtkvavkmlksdate
kdlsdlisememmkmigkhkniinllgactqdgplyvimeyaskgnlreylqarrqlssk
dlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglahidyykkttgrlp
vkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkps
nctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn