PDB entry 4rsc

View 4rsc on RCSB PDB site
Description: Crystal structure of RPE65 in complex with emixustat and palmitate
Class: isomerase
Keywords: 7-bladed beta propeller, monotopic membrane protein, non-heme iron enzyme, retinoid isomerase, smooth endoplasmic reticulum, ISOMERASE
Deposited on 2014-11-07, released 2015-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-06-03, with a file datestamp of 2015-05-29.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (Start-532)
      • conflict (340)
    Domains in SCOPe 2.08: d4rsca_
  • Chain 'B':
    Compound: Retinoid isomerohydrolase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28175 (Start-532)
      • conflict (340)
    Domains in SCOPe 2.08: d4rscb_
  • Heterogens: FE2, PLM, A3V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rscA (A:)
mssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhl
fdgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrff
syfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatah
phiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyv
hsfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyi
nnkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarka
pqpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpq
inyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdale
eddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >4rscA (A:)
sqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlfd
gqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafevtdnalvniypvg
edyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfiayn
ivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlfkfl
ssganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedheflivdlc
cwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknlvtlpnt
tatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfvpdrlck
lnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayllilnakd
lsevaraeveinipvtfhglfkks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rscB (B:)
mssqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhl
fdgqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpdpcknifsrff
syfrgvevtdnalvniypvgedyyactetnfitkvnpetletikqvdlcnyvsvngatah
phiendgtvynigncfgknfsiaynivkipplqadkedpiskseivvqfpcsdrfkpsyv
hsfgltpnyivfvetpvkinlfkflsswslwganymdcfesnetmgvwlhiadkkrkkyi
nnkyrtspfnlfhhintyedheflivdlccwkgfefvynylylanlrenweevkknarka
pqpevrryvlplnidkadtgknlvtlpnttatailcsdetiwlepevlfsgprqafefpq
inyqkyggkpytyayglglnhfvpdrlcklnvktketwvwqepdsypsepifvshpdale
eddgvvlsvvvspgagqkpayllilnakdlsevaraeveinipvtfhglfkks

    Sequence, based on observed residues (ATOM records): (download) 
    >4rscB (B:)
sqvehpaggykklfetveelsspltahvtgriplwltgsllrcgpglfevgsepfyhlfd
gqallhkfdfkeghvtyhrrfirtdayvramtekrivitefgtcafpgvevtdnalvniy
pvgedyyactetnfitkvnpetletikqvdlcnyvsvngatahphiendgtvynigncfi
aynivkipplqadkedpiskseivvqfpcsdrfkpsyvhsfgltpnyivfvetpvkinlf
kflganymdcfesnetmgvwlhiadkkrkkyinnkyrtspfnlfhhintyedheflivdl
ccwkgfefvynylylanlrenweevkknarkapqpevrryvlplnidkadtgknlvtlpn
ttatailcsdetiwlepevlfsgprqafefpqinyqkyggkpytyayglglnhfvpdrlc
klnvktketwvwqepdsypsepifvshpdaleeddgvvlsvvvspgagqkpayllilnak
dlsevaraeveinipvtfhglfkks